Ethanol → 5-Iodo-4-(1-methylhydrazino)-2-methylthiopyrimidine
Reaction equation
C(=O)([O-])[O-].[K+].[K+].C(O)C.Cl[C:11]1[C:16]([I:17])=[CH:15][N:14]=[C:13]([S:18][CH3:19])[N:12]=1.[CH3:20][NH:21][NH2:22]>O>[I:17][C:16]1[C:11]([N:21]([CH3:20])[NH2:22])=[N:12][C:13]([S:18][CH3:19])=[N:14][CH:15]=1Participants
6
Procedure
603 mg of potassium carbonate was added to ethanol (15 mL) solution of 1.25 g of 4-chloro-5-iodo-2-(methylthio)pyrimidine, and with cooling with ice, 0.28 mL of methylhydrazine was dropwise added thereto. This was stirred overnight at room temperature, then water was added thereto, and the precipitated crystal was taken out through filtration and dried to obtain 851 mg of the entitled compound as a white solid.
Workup
- additionwas dropwise added
- filtrationthe precipitated crystal was taken out through filtration
- customdried
Sources & evidence
- ORD record
- ord-3c11093a21044193a80f67683a9f7cbf
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07935708B2
Reaction notes
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