Methyl 7-chloroisoquinoline-3-carboxylate → 7-Chloroisoquinoline-3-carboxylic Acid Hydrochloride
Reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([O:14]C)=[O:13])[N:8]=[CH:9]2)=[CH:4][CH:3]=1>Cl>[ClH:1].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([OH:14])=[O:13])[N:8]=[CH:9]2)=[CH:4][CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Methyl 7-chloroisoquinoline-3-carboxylate (0.23 g) was dissolved in concentrated hydrochloric acid (10 ml) to heat the mixture for 18 hours under reflux. The temperature of the reaction mixture was dropped to room temperature, and deposits were collected by filtration and then washed with water to obtain the title compound (0.21 g) as a colorless solic.
Workup
- temperatureto heat the mixture for 18 hours
- temperatureunder reflux
- additionThe temperature of the reaction mixture was dropped to room temperature
- filtrationdeposits were collected by filtration
- washwashed with water
Sources & evidence
- ORD record
- ord-75f505b5fc6641e0b7f49079a3f232d4
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07935824B2
Reaction notes
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