HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 54825Generated: October 26, 2026
Lithium azide → 1,4-Anhydro-5-azido-5-deoxy-2-S-[(4-methoxyphenyl)-methyl]-2-thio-L-arabinitol
https://huagongshe.com/reaction/54825
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium azide | HCID 88163 | — |
| Reactant | 1,4-Anhydro-2-S-[(4-methoxyphenyl)methyl]-2-thio-L-arabinitol 5-(4-Methylbenzenesulfonate) | HCID 88337105 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1,4-Anhydro-5-azido-5-deoxy-2-S-[(4-methoxyphenyl)-methyl]-2-thio-L-arabinitol | HCID 131719993 | 32.6% |
Reaction Steps
A mixture of 2.0 g of product from Example 324, 0.460 g of lithium azide and 2 ml of N,N-dimethylformamide is stirred at 70° C. for 65 hours. The reaction mixture is concentrated in vacuo. The residue is purified by chromatography (Silica gel: 30% ethyl acetate/hexane) to give 0.454 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05623081 |
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| Source dataset | uspto-grants-1997_04 |
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| ORD ID | ord-5061bb5743e04cedafaf182a0c9038b8 |
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| Source note | uspto-grants-1997_04 |
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