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HRID54825

反应详情

EQUATION

反应方程式

HRID 54825 的结构方程式

REACTANTS

反应物

2
结构：[Li+].[N-]=[N+]=[N-]
HCID88163

Lithium azide

LiN3

结构：COc1ccc(CS[C@H]2CO[C@@H](COS(=O)(=O)c3ccc(C)cc3)[C@@H]2O)cc1
HCID88337105

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CS[C@H]2CO[C@@H](CN=[N+]=[N-])[C@@H]2O)cc1
HCID131719993

未命名化合物

收率 32.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
70 °C

PROCEDURE

实验过程

A mixture of 2.0 g of product from Example 324, 0.460 g of lithium azide and 2 ml of N,N-dimethylformamide is stirred at 70° C. for 65 hours. The reaction mixture is concentrated in vacuo. The residue is purified by chromatography (Silica gel: 30% ethyl acetate/hexane) to give 0.454 g of the desired product.

WORKUP

后处理

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customThe residue is purified by chromatography (Silica gel: 30% ethyl acetate/hexane)