Dichloromethane → 2-(5-Methylfuran-2-yl)ethan-1-amine

HRID 550622

Reaction equation

HRID 550622 reaction equation
C([N:3]([CH2:6][CH3:7])CC)C.[C:8]([O:11][C:12](=O)[CH3:13])(=O)[CH3:9].[CH2:15](Cl)Cl>>[CH3:9][C:8]1[O:11][C:12]([CH2:7][CH2:6][NH2:3])=[CH:13][CH:15]=1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 7918Acetic AnhydrideHCID 8471Triethylamine

Product 1

HCID 149337782-(5-Methylfuran-2-yl)ethan-1-amine

Procedure

To a solution of the amine C (1 mol) in CH2Cl2 (approx. 10 ml per 1 g of the starting compound) triethylamine (1.1 mol) and acetic anhydride (1.2 mol) were added. The reaction mixture is stirred at room temperature for 1 h and concentrated on rotary evaporator. The residue is triturated with hexane, filtered, washed with hexane to give a crystalline compound in good yields.

Workup

  1. concentrationconcentrated on rotary evaporator
  2. customThe residue is triturated with hexane
  3. filtrationfiltered
  4. washwashed with hexane
  5. customto give a crystalline compound in good yields

Sources & evidence

ORD record
ord-fecd54f676ab45f1abfe9f1bb1307074
Source dataset
uspto-grants-2011_05
Patent number
US07947689B2

Linked notes

Loading…