Water → 3-Chloro-4-(1,1-dioxo-[1,2]thiazinan-2-yl)-toluene

HRID 551222

Reaction equation

HRID 551222 reaction equation
[Cl:1][C:2]1[CH:16]=[C:15]([CH3:17])[CH:14]=[CH:13][C:3]=1[NH:4][S:5]([CH2:8][CH2:9][CH2:10][CH2:11]Cl)(=[O:7])=[O:6].[K].CC(C)([O-])C.O>CN(C=O)C>[Cl:1][C:2]1[CH:16]=[C:15]([CH3:17])[CH:14]=[CH:13][C:3]=1[N:4]1[CH2:11][CH2:10][CH2:9][CH2:8][S:5]1(=[O:7])=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 50987170Potassium tertbutoxideHCID 670486822-chloro-N-(4-chlorobutyl-sulphonyl)-4-methyl-aniline

Product 1

HCID 667317213-Chloro-4-(1,1-dioxo-[1,2]thiazinan-2-yl)-toluene

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.27 g (4.29 mmol) 2-chloro-N-(4-chlorobutyl-sulphonyl)-4-methyl-aniline are stirred together with 722 mg (6.43 mmol) potassium-tert.-butoxide in 50 ml DMF for 16 hours at 60° C. Then the reaction mixture is poured into water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate and evaporated down i. vac. The residue is purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=3:2).

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe combined organic phases are dried over sodium sulphate
  3. customevaporated down i
  4. customThe residue is purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=3:2)

Sources & evidence

ORD record
ord-b68109bcc540492b88f56ca57a1e6150
Source dataset
uspto-grants-2011_05
Patent number
US07947700B2

Linked notes

Loading…