Water → HCID 178504316, compound

HRID 55357

Reaction equation

HRID 55357 reaction equation
Cl[Si:2]([CH3:5])([CH3:4])[CH3:3].Cl.[OH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([NH2:14])[CH2:10][CH2:9]1.C(N(CC)CC)C.O>C(Cl)Cl>[CH3:3][Si:2]([CH3:5])([CH3:4])[O:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([NH2:14])[CH2:10][CH2:9]1

Participants

6

Reactant 4

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 8471TriethylamineHCID 178479278HCID 178479278, compound

Product 1

HCID 178504316HCID 178504316, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

A solution of 1.85 ml of chlorotrimethylsilane in 10 ml of CH2Cl2 is added dropwise to a solution of 2.0 g of trans-4-hydroxycyclohexylamine hydrochloride and 4.05 ml of triethylamine in 20 ml of CH2Cl2, cooled to 0° C. After stirring for 16 hours at room temperature, the mixture is hydrolyzed with water and extracted. The organic phase is washed successively with water, a 5% solution of Na2CO3 and saturated NaCl. After drying over MgSO4 and evaporation of the solvents, 1.43 g of amine (colorless liquid) are obtained.

Workup

  1. extractionextracted
  2. washThe organic phase is washed successively with water
  3. dry with materialAfter drying over MgSO4 and evaporation of the solvents, 1.43 g of amine (colorless liquid)
  4. customare obtained

Sources & evidence

ORD record
ord-0057d01bc02e48f187b6f212ae0adc0e
Source dataset
uspto-grants-1997_04
Patent number
US05624941

Linked notes

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