HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 15-Crown-5 | HCID 36336 | — |
| Reactant | 2,3-Dihydro-1,4-benzodioxine-6-sulfonyl chloride | HCID 2776169 | — |
| Reactant | 4-Methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 71362812 | — |
| Product | 1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620764 | 102.1% |
Reaction Steps
Using 4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde (185 mg), sodium hydride (60% in oil, 72 mg), 15-crown-5 (330 mg) and 2,3-dihydro-1,4-benzodioxine-6-sulfonyl chloride (352 mg), a procedure as in Reference Example 219 was performed to give the title compound as a pale-yellow oil (yield 391 mg, about 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048909B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-40076bb8c6544a08ade255d80711295f |
| Source note | uspto-grants-2011_11 |