N-Methylaniline → 6-(5-Chloro-2-methoxybenzyl)-n-{(1r)-1-[(methylanilino)carbonyl]propyl}-3,7-dioxo-1,4-diazepan-1-carboxamide

HRID 554788

Reaction equation

HRID 554788 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22][CH2:23][C:24](OC(C)(C)C)=O)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.[C:38](OC(=O)CN)(C)(C)C.CN[C:49]1[CH:54]=CC=[CH:51][CH:50]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@@H:19]([C:20]([N:22]([CH3:38])[C:23]2[CH:51]=[CH:50][CH:49]=[CH:54][CH:24]=2)=[O:21])[CH2:31][CH3:32])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1

Participants

4

Reactant 3

HCID 7515N-MethylanilineHCID 2725036Glycine tert-butyl ester hydrochlorideHCID 76588771Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate

Product 1

HCID 576709086-(5-Chloro-2-methoxybenzyl)-n-{(1r)-1-[(methylanilino)carbonyl]propyl}-3,7-dioxo-1,4-diazepan-1-carboxamide

Procedure

Instead of the starting material compound of Example 220, that is, glycine tert-butyl ester hydrochloride, N-methylaniline was used for the similar procedure as in Example 220 to obtain the title compound.

Sources & evidence

ORD record
ord-a868824350d14f819c013645ea9b97ab
Source dataset
uspto-grants-2011_11
Patent number
US08049006B2

Linked notes

Loading…