Glycolic Acid → HCID 178519921, compound

HRID 55502

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[C:10](O)(=O)[CH2:11][OH:12]>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[C:10]([CH2:11][OH:12])[NH:8][C:5]2=[N:6][CH:7]=1

Participants

Reactant 2

HCID 757Glycolic Acid

HCID 6911565-Bromopyridine-2,3-diamine

Product 1

HCID 178519921HCID 178519921, compound

Procedure

A procedure similar to that described in Preparation 43 was repeated, except that 7.00 g of 5-bromo-2,3-diaminopyridine (prepared as described in Preparation 57) and 8.50 g of glycolic acid were used, to give the title compound as a crude product. This crude product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 7.05 g of the title compound, melting at 230°-233° C.

Workup

customA procedure similar to that described in Preparation 43

Sources & evidence

ORD record: ord-258830a8cec74256ae7bf551b8976fb9
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05624935

Linked notes

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