Bromoacetonitrile → (4-Ethylpiperazin-1-yl)acetonitrile

Reaction equation

[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].Br[CH2:10][C:11]#[N:12]>>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:10][C:11]#[N:12])[CH2:5][CH2:4]1)[CH3:2]

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 791961-Ethylpiperazine

Product 1

HCID 22688890(4-Ethylpiperazin-1-yl)acetonitrile

Procedure

The title compound is synthesized by coupling of 1-Ethyl-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a orange oil; ES-MS: M+=154.1: 1HNMR(DMSO-d6) 3.70 (s, 2H), 2.40-2.20 (m, 10H), 0.95 (t, 3H).

Sources & evidence

ORD record: ord-afeccc5d3e064fe89e881a26b52a4572
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08053457B2

Reaction notes

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