Methyl iodide → 3-Methoxy-2-nitropyridine

HRID 556509Notes

Reaction equation

HRID 556509 reaction equation
[N+:1]([C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][N:5]=1)([O-:3])=[O:2].[C:11](=O)([O-])[O-].[K+].[K+].CI>>[CH3:11][O:10][C:9]1[C:4]([N+:1]([O-:3])=[O:2])=[N:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 270573-Hydroxy-2-nitropyridine

Product 1

HCID 5560633-Methoxy-2-nitropyridineYield 97.4%

Procedure

The similar reaction as described in Reference Example 9 by using 2-nitro-3-hydroxypyridine (7.0 g), potassium carbonate (6.91 g) and methyl iodide (4.67 ml) gave the title compound (7.5 g) as crystalline powders.

Workup

  1. customThe similar reaction

Sources & evidence

ORD record
ord-756d09c03e2646658d6e0c70c3ed0126
Source dataset
uspto-grants-2011_11
Patent number
US08058280B2

Reaction notes

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