Thioacetamide → 2-Methyl-5-p-tolyl-thiazole-4-carboxylic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1.[C:16]([NH2:19])(=[S:18])[CH3:17]>>[CH3:1][O:2][C:3]([C:4]1[N:19]=[C:16]([CH3:17])[S:18][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1)=[O:15]Participants
3
Procedure
prepared by reaction of 3-chloro-2-oxo-3-p-tolyl-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.92 min; [M+H]+=248.2.
Sources & evidence
- ORD record
- ord-3b4f4a9f7aa949648c0b0393c1b0077d
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08063099B2
Reaction notes
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