Thioacetamide → Methyl 5-(2-fluorophenyl)-2-methyl-4-thiazolecarboxylate
Reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[F:12].[C:16]([NH2:19])(=[S:18])[CH3:17]>>[CH3:1][O:2][C:3]([C:4]1[N:19]=[C:16]([CH3:17])[S:18][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[F:12])=[O:15]Participants
3
Procedure
prepared by reaction of 3-chloro-3-(2-fluoro-phenyl)-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.89 min; [M+H]+=252.0.
Sources & evidence
- ORD record
- ord-948cff0ff0164719a0cd052c970d3605
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08063099B2
Reaction notes
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