Ethyl Acetate → Ethyl 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-hydroxybutanoate

HRID 561428

Reaction equation

HRID 561428 reaction equation
[CH3:1][C:2]([C:4]1[CH:13]=[CH:12][C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[CH:5]=1)=[O:3].[C:14]([O:17][CH2:18][CH3:19])(=[O:16])[CH3:15].ClC1C=CC(C(C2CC2)(O)CC(OCC)=O)=CC=1>>[O:8]1[C:7]2[CH:12]=[CH:13][C:4]([C:2]([OH:3])([CH3:1])[CH2:15][C:14]([O:17][CH2:18][CH3:19])=[O:16])=[CH:5][C:6]=2[O:11][CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 761431,4-Benzodioxan-6-yl methyl ketoneHCID 12168030Ethyl 3-(4-chlorophenyl)-3-cyclopropyl-3-hydroxypropanoate

Product 1

HCID 55071354Ethyl 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-hydroxybutanoate

Procedure

The title compound was prepared starting from 2.00 g (11.22 mmol) of 1,4-benzodioxan-6-yl methyl ketone and 4.74 ml (22.45 mmol) of ethyl acetate in analogy to the synthesis of the compound from Example 90A. 2.52 g (84% of theory) of the title compound were obtained.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-3892df53b6a5442aa0b47281c1bdbe2d
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Linked notes

Loading…