HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-fluoro-N-(4-morpholinobutyl)-4-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Reactant | 4-(Morpholin-4-yl)butan-1-amine | HCID 233611 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-fluoro-N-(4-morpholinobutyl)-4-nitroaniline | HCID 117966064 | — |
Reaction Steps
A suspension of 4-morpholinobutan-1-amine (0.63 g, 4.00 mmol), 1,2-difluoro-4-nitrobenzene (0.64 g, 4.00 mmol) and K2CO3 (1.10 g, 8.00 mmol) in acetonitrile (20 mL) was stirred at rt for 19 h under N2, then filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434695B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-3a675810b1134632b765617e574da304 |
| Source note | uspto-grants-2016_09 |