Potassium Carbonate → 2-fluoro-N-(4-morpholinobutyl)-4-nitroaniline

HRID 56169Notes

Reaction equation

HRID 56169 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH2:3][CH2:2]1.F[C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:14]=1[F:22].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[F:22][C:14]1[CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=[CH:18][C:13]=1[NH:11][CH2:10][CH2:9][CH2:8][CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 2336114-(Morpholin-4-yl)butan-1-amine

Product 1

HCID 1179660642-fluoro-N-(4-morpholinobutyl)-4-nitroaniline

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of 4-morpholinobutan-1-amine (0.63 g, 4.00 mmol), 1,2-difluoro-4-nitrobenzene (0.64 g, 4.00 mmol) and K2CO3 (1.10 g, 8.00 mmol) in acetonitrile (20 mL) was stirred at rt for 19 h under N2, then filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

Workup

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-3a675810b1134632b765617e574da304
Source dataset
uspto-grants-2016_09
Patent number
US09434695B2

Reaction notes

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