Imidazole → 2-(2,6-Dichloro-4-methylphenoxy)ethan-1-ol

HRID 561839

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[OH:10].C1(=O)O[CH2:14][CH2:13][O:12]1.N1C=CN=C1>>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[O:10][CH2:14][CH2:13][OH:12]

Participants

Reactant 3

HCID 795Imidazole

HCID 7303Ethylene carbonate

HCID 170772,6-Dichloro-4-methylphenol

Product 1

HCID 213969022-(2,6-Dichloro-4-methylphenoxy)ethan-1-ol

Conditions

Temperature: 150 °C

Procedure

2,6-Dichloro-4-methylphenol (1 eq.), ethylene carbonate (1 eq.) and imidazole (0.5% loading) were combined and heated at 150° C. for 4 h to afford the title compound as a brown oil.

Sources & evidence

ORD record: ord-1ab1a93deda14501b292e7f6ce123d80
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063105B2

Linked notes

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