Ammonium Hydroxide → 2-(Cyclohexyloxy)acetamide
Reaction equation
[NH4+:1].[OH-].[CH:3]1([O:9][CH2:10][C:11](Cl)=[O:12])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>C(Cl)Cl>[CH:3]1([O:9][CH2:10][C:11]([NH2:1])=[O:12])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 15 mL of NH4OH (25-28%) was added a solution of 2-(cyclohexyloxy)acetyl chloride (1.01 g, 5.72 mmol) in DCM (2 mL) in an ice bath and the mixture was stirred at rt for 5 min and extracted with DCM (20 mL×3). The combined organic layers were washed with brine (20 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a white solid (0.5 g, 56%).
Workup
- extractionextracted with DCM (20 mL×3)
- washThe combined organic layers were washed with brine (20 mL×2)
- dry with materialdried over anhydrous Na2SO4
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-4c29a6eefae0405481d333a91e564b39
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434695B2
Reaction notes
Loading…