Chlorosuccinimide → Methyl 2-(3-chloro-5-cyano-4-hydroxyphenyl)isonicotinate

HRID 562890

Reaction equation

HRID 562890 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:10]2[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=2)[C:13]([O:15][CH3:16])=[O:14])[CH:6]=[CH:7][C:8]=1[OH:9])#[N:2].[Cl:20]N1C(=O)CCC1=O>C(#N)C>[Cl:20][C:7]1[CH:6]=[C:5]([C:10]2[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=2)[C:13]([O:15][CH3:16])=[O:14])[CH:4]=[C:3]([C:1]#[N:2])[C:8]=1[OH:9]

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 136368377Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate

Product 1

HCID 136368378Methyl 2-(3-chloro-5-cyano-4-hydroxyphenyl)isonicotinate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate and N-chlorosuccinimide were stirred at room temperature in acetonitrile to obtain methyl 2-(3-chloro-5-cyano-4-hydroxyphenyl)isonicotinate. ES: 289.

Sources & evidence

ORD record
ord-3bf5b5cf85fd4644a306df1eddf6503d
Source dataset
uspto-grants-2011_11
Patent number
US08067446B2

Linked notes

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