1-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one dihydrochloride → HCID 178521227, compound

HRID 56348

Reaction equation

HRID 56348 reaction equation
[Cl:1][C:2]1[C:3]([C:7]([OH:9])=O)=[N:4][NH:5][CH:6]=1.Cl.Cl.[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:27])[CH2:20][N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:15][CH:14]=1>>[Cl:1][C:2]1[C:3]([C:7]([N:24]2[CH2:23][CH2:22][N:21]([CH2:20][C:19]([C:16]3[CH:17]=[CH:18][C:13]([F:12])=[CH:14][CH:15]=3)=[O:27])[CH2:26][CH2:25]2)=[O:9])=[N:4][NH:5][CH:6]=1

Participants

3

Reactant 2

HCID 429337161-(4-Fluorophenyl)-2-(piperazin-1-yl)ethan-1-one dihydrochlorideHCID 178524948HCID 178524948, compound

Product 1

HCID 178521227HCID 178521227, compoundYield 65.3%

Procedure

The title compound was prepared in a similar manner as described in Example 1.2, using 4-chloro-1H-pyrazole-3-carboxylic acid (22.0 mg), and 1-(4-fluorophenyl)-2-(piperazin-1-yl)ethanone dihydrochloride (29.5 mg) as starting materials, to afford the title compound (22.9 mg) as a white solid. Exact mass calculated for C16H16ClFN4O2: 350.1. Found: LCMS m/z (%)=351.3 (M+H+35Cl, 100%), 353.3 (M+H+37Cl, 32%).

Workup

  1. customThe title compound was prepared in a similar manner

Sources & evidence

ORD record
ord-a3055e906fc847649f9027cead46efa8
Source dataset
uspto-grants-2016_09
Patent number
US09434692B2

Linked notes

Loading…