4-Chlorobenzoic Acid → 2-[[4-(4-Chlorobenzoyl)-1-piperazinyl]methyl]-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamine

HRID 565647

Reaction equation

HRID 565647 reaction equation
[CH3:1][C:2]1([CH2:15][N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[CH2:6][C:5]2[C:7]([CH3:14])=[C:8]([NH2:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=2[O:3]1.[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([N:19]2[CH2:20][CH2:21][N:16]([CH2:15][C:2]3([CH3:1])[CH2:6][C:5]4[C:7]([CH3:14])=[C:8]([NH2:13])[C:9]([CH3:12])=[C:10]([CH3:11])[C:4]=4[O:3]3)[CH2:17][CH2:18]2)=[O:28])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 63184-Chlorobenzoic AcidHCID 219977792,3-Dihydro-2,4,6,7-tetramethyl-2-[(1-piperazinyl)methyl]-5-benzofuranamine

Product 1

HCID 221109622-[[4-(4-Chlorobenzoyl)-1-piperazinyl]methyl]-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamineYield 64%

Procedure

Using 2,3-dihydro-2,4,6,7-tetramethyl-2-[(1-piperazinyl)methyl]-5-benzofuranamine and 4-chlorobenzoic acid, the procedure of Example 10, presented hereinafter, was otherwise followed to provide the title compound. Yield 64%.

Sources & evidence

ORD record
ord-dcb77a91d14446c6bae1787799e26a7f
Source dataset
uspto-grants-2001_01
Patent number
US06172085B2

Linked notes

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