Diethyl benzylphosphonate → Benzylphosphonic Acid

HRID 565992

Reaction equation

HRID 565992 reaction equation
[CH2:1]([P:8](=[O:15])([O:12]CC)[O:9]CC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.Cl>[CH2:1]([P:8](=[O:9])([OH:15])[OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 14122Diethyl benzylphosphonate

Product 1

HCID 81312Benzylphosphonic AcidYield 59.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A solution of diethyl benzylphosphonate (25 g) in methanol (10 ml) and concentrated hydrochloric acid (500 ml) solution was refluxed for 4 days. The mixture was cooled to room temperature, and precipitated crystal was collected by filtration to give benzylphosphonic acid (11.17 g) as colorless crystals.

Workup

  1. customprecipitated crystal
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-dde78dcacfcc4ea3b3cf341bf25c2323
Source dataset
uspto-grants-2001_01
Patent number
US06172061B2

Linked notes

Loading…