Hydrochloric Acid → 3-Fluoro-N-methoxy-N-methylbenzamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[CH3:11][NH:12][O:13][CH3:14].Cl.N1C=CC=CC=1>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([N:12]([O:13][CH3:14])[CH3:11])=[O:6]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To a mixture of 3-fluorobenzoyl chloride (11.0 g, 6.70 mmol) and N,O-dimethylhydroxylamine.HCl in CHCl3 (70 mL) at 0° C. was added pyridine (14 mL) over 30 min. After a period of 3 h at room temperature, the reaction mixture was treated in the usual manner to give 12.5 g of the title compound.
Workup
- additionthe reaction mixture was treated in the usual manner
Sources & evidence
- ORD record
- ord-2499919546844c4493cec1cc97ddddbf
- Source dataset
- uspto-grants-2001_01
- Patent number
- US06174874B1
Reaction notes
Loading…