Methanol → HCID 13765545, compound

HRID 568759

Reaction equation

HRID 568759 reaction equation
CO.[Cl:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][OH:12].[CH2:13]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[CH3:14]>>[Cl-:3].[CH2:13]([N+:15]([CH2:18][CH3:19])([CH2:16][CH3:17])[CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][OH:12])[CH3:14]

Participants

4

Reactant 3

HCID 887MethanolHCID 8471TriethylamineHCID 788712-(2-(2-Chloroethoxy)ethoxy)ethanol

Product 1

HCID 13765545HCID 13765545, compoundYield 95%

Conditions

Temperature
130 °C

Procedure

An autoclave (capacity: 500 ml) was charged with 200 parts of methanol and 94.5 parts of triethylamine. After heating the mixture to 130° C., 135 parts of 2-[2-(2-chloro-ethoxy)ethoxy]ethanol was added over a period of 1 hour and the resulting mixture was heated at 130° C. for an additional 4 hours. Crystallization was performed as in Preparation 1 to obtain 205.0 parts of triethyl 2-[2-(2-hydroxy-ethoxy)ethoxy]ethylammonium chloride (yield: 95%).

Workup

  1. temperaturethe resulting mixture was heated at 130° C. for an additional 4 hours
  2. customCrystallization
  3. customwas performed as in Preparation 1

Sources & evidence

ORD record
ord-26b0fae42e79469cbdc05ee0a34b39ab
Source dataset
uspto-grants-1988_03
Patent number
US04729941

Linked notes

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