Hydrochloric Acid → HCID 14098168, compound

Reaction equation

[Cl:1][CH2:2][CH2:3][CH2:4][C:5]1([CH2:19][CH2:20][C:21](=[O:23])[CH3:22])[CH2:13][C:12]2[C:7](=[C:8]([Cl:17])[C:9]([Cl:16])=[C:10]([O:14][CH3:15])[CH:11]=2)[C:6]1=O.[OH-].[Na+].Cl>CO>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]12[CH2:19][CH2:20][C:21](=[O:23])[CH:22]=[C:6]1[C:7]1[C:12](=[CH:11][C:10]([O:14][CH3:15])=[C:9]([Cl:16])[C:8]=1[Cl:17])[CH2:13]2

Participants

Procedure

2-(3-Chloropropyl)-6,7-dichloro-2,3-dihydro-5-methoxy-2-(3-oxobutyl)-1H-inden-1-one (36 g, 0.0053 mole) was dissolved in methanol (4.75 ml) containing 10% aqueous sodium hydroxide (190 ml). Then stirred and refluxed for 3 hours. The solution was cooled, poured into crushed ice, acidified with hydrochloric acid and the solid that separated removed by filtration. The solid washed on the filter with water, dried and recrystallized from a mixture of tetrahydrofuran and ether to give 9a-(3-chloropropyl)-5,6-dichloro-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one, 15 g, m.p. 183°-185° C.