Tetrahydrofuran → 2,1-Benzisothiazole-6-carboxaldehyde
Reaction equation
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]2=[CH:7][S:8][N:9]=[C:5]2[CH:4]=1.O1CCCC1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[N:9]1[S:8][CH:7]=[C:6]2[CH:10]=[CH:11][C:3]([CH:2]=[O:1])=[CH:4][C:5]=12Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
1.65 g (10 mmol) of 10b are stirred analogously to Example 1b in 100 ml of CH2Cl2 and 30 ml of tetrahydrofuran with 5.5 g (63.4 mmol) of manganese(IV) oxide at room temperature overnight.
Workup
- customat room temperature
- customovernight
Sources & evidence
- ORD record
- ord-e42d5361e2b241298e430638130ab6a6
- Source dataset
- uspto-grants-1988_03
- Patent number
- US04734407
Reaction notes
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