Lithium Hydroxide → alpha-Amino-alpha-(2,1-benzisothiazol-6-yl)acetic acid
Reaction equation
[N:1]1[S:2][CH:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH:10]3[NH:14]C(=O)N[C:11]3=[O:16])=[CH:6][C:5]=12.[OH-:17].[Li+]>O>[NH2:14][CH:10]([C:7]1[CH:8]=[CH:9][C:4]2=[CH:3][S:2][N:1]=[C:5]2[CH:6]=1)[C:11]([OH:16])=[O:17]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
16.5 g (0.071 mole) of 10d are heated under reflux analogously to Example 3e with 17.0 g (0.71 mole) of lithium hydroxide in 250 ml of water for 20 hours.
Sources & evidence
- ORD record
- ord-4c4c97a222c744318ba7490b91efe412
- Source dataset
- uspto-grants-1988_03
- Patent number
- US04734407
Reaction notes
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