1H-Pyrazolo(3,4-d)pyrimidine → HCID 178506576, compound
Reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[N:8][CH:9]=[C:4]2[CH:3]=[N:2]1.[I:10]N1C(=O)CCC1=O>CN(C=O)C>[I:10][C:3]1[C:4]2[C:5](=[N:6][CH:7]=[N:8][CH:9]=2)[NH:1][N:2]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
520 mg (4.331 mmol) of 1H-pyrazolo[3,4-d]pyrimidine and 1.461 g (6.496 mmol) of N-iodosuccinimide were dissolved in 10 ml of DMF and the mixture was heated at 80° C. for 3 h. After cooling, the mixture was concentrated on a rotary evaporator and the residue was stirred with dichloromethane, filtered off with suction and dried under high vacuum. 569 mg (53% of theory) of the target compound were obtained.
Workup
- temperatureAfter cooling
- concentrationthe mixture was concentrated on a rotary evaporator
- filtrationfiltered off with suction
- customdried under high vacuum
- custom569 mg (53% of theory) of the target compound were obtained
Sources & evidence
- ORD record
- ord-a880a7ad8070471db5b646bbf75b8202
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09023849B2
Reaction notes
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