Trifluoroacetic acid → 2-(6-Morpholino-2,3-dioxoindolin-1-yl)acetic acid
Reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:15]=[C:14]3[C:10]([C:11](=[O:25])[C:12](=[O:24])[N:13]3[CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:15]=[C:14]3[C:10]([C:11](=[O:25])[C:12](=[O:24])[N:13]3[CH2:16][C:17]([OH:19])=[O:18])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of tert-butyl 2-(6-morpholino-2,3-dioxoindolin-1-yl)acetate (0.400 g, 1.155 mmol) in DCM (10 ml), TFA (1.716 ml, 23.10 mmol) was added drop wise. The resulting red solution was stirred at room temperature overnight. The volatiles were evaporated under vacuum to afford 2-(6-morpholino-2,3-dioxoindolin-1-yl)acetic acid (0.330 g, 1.137 mmol, 98% yield). MS/ESI+ 291.1 [MH]+.