4-Methylmorpholine → HCID 178474882, compound

HRID 57265

Reaction equation

HRID 57265 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1.[NH2:21][CH2:22][CH2:23][NH:24][C:25](=[O:27])[CH3:26].CN1CCOCC1>CO>[NH2:1][C:2]1[NH:6][N:5]=[C:4]([CH3:7])[C:3]=1[C:8]1[S:9][C:10]2[CH:16]=[C:15]([S:17]([NH:21][CH2:22][CH2:23][NH:24][C:25](=[O:27])[CH3:26])(=[O:19])=[O:18])[CH:14]=[CH:13][C:11]=2[N:12]=1

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 66082N-(2-aminoethyl)acetamideHCID 178434647HCID 178434647, compound

Product 1

HCID 178474882HCID 178474882, compoundYield 43.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

the title compound (52 mg) was prepared from crude 2-(5-amino-3-methyl-1H-pyrazol-4-yl)-benzothiazole-6-sulfonyl chloride (100 mg, 0.30 mmol), N-(2-aminoethyl)-acetamide (58 μL, 0.60 mmol) and PS-NMM (0.320 g, 0.60 mmol) in 5 mL of methanol. MS (m/z, ES+): 395.6 (M+1, 100%). Yield=43%.

Sources & evidence

ORD record
ord-d59806c7a5904aafad5a23f76c1d8133
Source dataset
uspto-grants-2016_09
Patent number
US09434720B2

Linked notes

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