Hydrochloric Acid → HCID 86719109, compound
Reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([O:12][CH3:13])=[O:11])=[N:7][CH:8]=1)#[N:2].[ClH:14]>CO.[Pd]>[Cl-:14].[CH3:13][O:12][C:10](=[O:11])[CH2:9][C:6]1[N:7]=[CH:8][C:3]([CH2:1][NH3+:2])=[CH:4][CH:5]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of methyl 2-(5-cyanopyridin-2-yl)acetate (1.2 g, 6.8 mmol) in methanol (20 ml) was added hydrogen chloride in methanol (4 M, 20 ml), and then Pd/C (200 mg). Then the reaction mixture was hydrogenated under hydrogen atmosphere overnight. The reaction mixture was filtered, the filtrate was concentrated to give the crude product and was washed by ethyl acetate to give the desired product. LC-MS: m/z (M+H)=181.5
Workup
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated
- customto give the crude product
- washwas washed by ethyl acetate
Sources & evidence
- ORD record
- ord-38f2c37d53e74c9b8eea0362ab7f6988
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09029531B2
Reaction notes
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