Hydrochloric Acid → 1-(Oxan-4-yl)piperidin-4-amine dihydrochloride

HRID 573057

Reaction equation

HRID 573057 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:21]>ClCCl>[ClH:21].[ClH:21].[O:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 45792109tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate

Product 1

HCID 451567511-(Oxan-4-yl)piperidin-4-amine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of EXAMPLE 49A (52.57 g) in dichloromethane (900 mL) was treated with 4M aqueous HCl (462 mL), mixed vigorously at room temperature for 16 hours and concentrated.

Workup

  1. additionmixed vigorously at room temperature for 16 hours
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-566ffc0d7f9a483cbd122321a5bfab02
Source dataset
uspto-grants-2015_05
Patent number
US09029404B2

Linked notes

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