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HCID 66728062, compound → HCID 86688956, compound

HRID 573266
Notes
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Reaction equation

HRID 573266 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)=[CH:3]1>CO.CCOC(C)=O.[Pd]>[CH3:1][N:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)=[CH:3]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 1

HCID 66728062HCID 66728062, compound

Product 1

HCID 86688956HCID 86688956, compoundYield 98.7%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1-methyl-3-(4-nitrophenyl)-1H-pyrrolo[3,2-b]pyridine (85 mg) and 10% Pd—C (50% wet, 100 mg) in MeOH (4 mL) and AcOEt (4 ml) was stirred under H2 atmosphere (balloon) for 4 h. After this time, the reaction was filtered and the filtrate was concentrated under reduced pressure to give the title compound (74 mg).

Workup

  1. filtrationAfter this time, the reaction was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1ed33ae3e03047f29639ca9012130cf9
Source dataset
uspto-grants-2015_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09029536B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes