Hydrochloric Acid → 1-Cyclobutylpiperazine hydrochloride

HRID 574167Notes

Reaction equation

HRID 574167 reaction equation
[CH:1]1([N:5]2[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[ClH:18]>CO>[ClH:18].[CH:1]1([N:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57423951Tert-butyl 4-cyclobutylpiperazine-1-carboxylate

Product 1

HCID 230903791-Cyclobutylpiperazine hydrochlorideYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To the mixture of tert-butyl 4-cyclobutylpiperazine-1-carboxylate (48 g, 200 mmol) in MeOH (100 mL) was added 2.0 M HCl in MeOH (400 mL) carefully at 0° C. The mixture was stirred at rt for 5 h, concentrated under reduced pressure to afford the desired compound 1-cyclobutylpiperazine hydrochloride (35 g, 82%) [LCMS: Rt=0.94 min, m/z 141.3 (M+H)+].

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-0f9117a098e84406bf009e2d1faac3c8
Source dataset
uspto-grants-2015_05
Patent number
US09034874B2

Reaction notes

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