Ammonium Hydroxide → 6-Chloro-2-methylpyrimidin-4-amine

Charge a 5 L steel pressure vessel (autoclave) with 4,6-dichloro-2-methylpyrimidine (400 g, 2.45 mol) and ammonium hydroxide (2.8 L) at RT. Heat the reaction to 90° C. for 5 h. Cool the reaction mixture to RT and then filter the solid through a Buchner funnel. Wash the filtercake with water (200 mL) and hexane (200 mL) and then dry under vacuum to afford the title compound as a white solid (290 g, 82%). LC-ES/MS m/z 144.0 (M+1).

1. temperatureHeat
2. customthe reaction to 90° C. for 5 h
3. filtrationfilter the solid through a Buchner funnel
4. washWash the filtercake with water (200 mL) and hexane (200 mL)
5. customdry under vacuum

ORD record

ord-889e43dc4de442488dae8be6d25a24e1

Source dataset

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09035051B1