Sodium Hydroxide → 1-(4-Nitrophenyl)piperidine-4-carboxylic acid

HRID 57573

Reaction equation

HRID 57573 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([O:18]C)=[O:17])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+]>CO.O>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:11][CH2:12][CH:13]([C:16]([OH:18])=[O:17])[CH2:14][CH2:15]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 345002Methyl 1-(4-nitrophenyl)piperidine-4-carboxylate

Product 1

HCID 27672651-(4-Nitrophenyl)piperidine-4-carboxylic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of methyl 1-(4-nitrophenyl)piperidine-4-carboxylate (3.84 g, 14.53 mmol) and NaOH (0.87 g, 21.79 mmol) in 15 mL of MeOH and 5 mL of water was stirred at room temperature for 3 hours. The volatiles were removed in vacuo to give 1-(4-nitrophenyl)piperidine-4-carboxylic acid.

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-00fa39b73d6247129b757153de89aac4
Source dataset
uspto-grants-2016_09
Patent number
US09434726B2

Linked notes

Loading…