HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-(4-Nitrophenyl)piperidine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 1-(4-nitrophenyl)piperidine-4-carboxylate | HCID 345002 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(4-Nitrophenyl)piperidine-4-carboxylic acid | HCID 2767265 | — |
Reaction Steps
A solution of methyl 1-(4-nitrophenyl)piperidine-4-carboxylate (3.84 g, 14.53 mmol) and NaOH (0.87 g, 21.79 mmol) in 15 mL of MeOH and 5 mL of water was stirred at room temperature for 3 hours. The volatiles were removed in vacuo to give 1-(4-nitrophenyl)piperidine-4-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-00fa39b73d6247129b757153de89aac4 |
| Source note | uspto-grants-2016_09 |