6-((Dibenzylamino)methyl)morpholin-3-one → 6-(Aminomethyl)morpholin-3-one
Reaction equation
C([N:8]([CH2:16][CH:17]1[CH2:22][NH:21][C:20](=[O:23])[CH2:19][O:18]1)CC1C=CC=CC=1)C1C=CC=CC=1>CCO.[OH-].[OH-].[Pd+2]>[NH2:8][CH2:16][CH:17]1[CH2:22][NH:21][C:20](=[O:23])[CH2:19][O:18]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 6-((dibenzylamino)methyl)morpholin-3-one (340 mg, 1.09 mmol), Pd(OH)2/C (170 mg) in EtOH (30 mL) was stirred equipped under H2 balloon overnight. The solution was filtered and concentrated to give white oil. The crude product was used directly for next step without purification.
Workup
- customequipped under H2 balloon overnight
- filtrationThe solution was filtered
- concentrationconcentrated
- customto give white oil
- customThe crude product was used directly for next step without purification
Sources & evidence
- ORD record
- ord-bbc83b480d1644d2811adaf60dc45bb8
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434726B2
Reaction notes
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