Triphenylborane → Butyl ethyl(3-aminopropyl)phosphinate

HRID 576019

Reaction equation

HRID 576019 reaction equation
[CH2:1]([P:3]([CH2:10][CH:11](C)[CH2:12][NH2:13])(=[O:9])[O:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:2].C1(B(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([P:3]([CH2:10][CH2:11][CH2:12][NH2:13])(=[O:9])[O:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:2]

Participants

4

Reactant 2

HCID 70400TriphenylboraneHCID 46212766Butyl ethyl(2-methyl-3-aminopropyl)phosphinate

Product 1

HCID 46212699Butyl ethyl(3-aminopropyl)phosphinateYield 216.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

207 g (1 mol) of butyl ethyl(3-aminopropyl)phosphinate (produced as in Example 15) and 242 g (1 mol) of triphenylborane are stirred in 400 ml of toluene at room temperature for 1 hour. Toluene is distilled off at reduced pressure to leave 449 g (100% of theory) of butyl ethyl(3-aminopropyl)phosphinate as triphenylborane adduct.

Workup

  1. distillationToluene is distilled off at reduced pressure

Sources & evidence

ORD record
ord-c43a7e6d12634605955e22ca7a853a9c
Source dataset
uspto-grants-2015_05
Patent number
US09035088B2

Linked notes

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