Borane → ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate
Reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:7]2[CH2:16][CH2:17][C:18](OCC)=[O:19].B>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:7]2[CH2:16][CH2:17][CH2:18][OH:19]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a mixture of EXAMPLE 1A (1.85 g) in THF (50 mL) was added 1M borane.THF (30 mL). The mixture was stirred at room temperature for 16 hours, quenched with methanol (10 mL) and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5-25% ethyl acetate/hexanes.
Workup
- customquenched with methanol (10 mL)
- concentrationconcentrated
- customThe concentrate was purified by flash column chromatography on silica gel with 5-25% ethyl acetate/hexanes
Sources & evidence
- ORD record
- ord-b8fb5e5297404142bfebb34bfd77fc8f
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09035047B2
Reaction notes
Loading…