Hydrochloric Acid → 4-Amino-2-[(2-aminoethyl)amino]-1,3-thiazol-5-carbonitrile dihydrochloride
Reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([NH:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)[S:5][C:6]=1[C:7]#[N:8].[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[NH2:1][C:2]1[N:3]=[C:4]([NH:9][CH2:10][CH2:11][NH2:12])[S:5][C:6]=1[C:7]#[N:8]Participants
4
Procedure
2.18 g (7.7 mmol) of tert-butyl {2-[(4-amino-5-cyano-1,3-thiazol-2-yl)amino]ethyl}carbamate (Example 7A) in 100 ml of 4N hydrogen chloride in dioxane were stirred at RT for 30 min. The reaction mixture was concentrated. This gave 2 g (100% of theory) of the product as a solid.
Workup
- concentrationThe reaction mixture was concentrated
Sources & evidence
- ORD record
- ord-4e01877cecb4433da588b196feb21f71
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434731B2
Reaction notes
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