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Hydrochloric Acid → (S)-methyl 2-((2-aminobutyl)amino)-2-oxoacetate hydrochloride

HRID 576697
Notes
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Reaction equation

HRID 576697 reaction equation
[ClH:1].C(OC([NH:9][C@@H:10]([CH2:19][CH3:20])[CH2:11][NH:12][C:13](=[O:18])[C:14]([O:16][CH3:17])=[O:15])=O)(C)(C)C>O1CCOCC1>[ClH:1].[NH2:9][C@@H:10]([CH2:19][CH3:20])[CH2:11][NH:12][C:13](=[O:18])[C:14]([O:16][CH3:17])=[O:15]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90402569(S)-methyl 2-((2-((tert-butoxycarbonyl)amino)butyl)amino)-2-oxoacetate

Product 1

HCID 90402534(S)-methyl 2-((2-aminobutyl)amino)-2-oxoacetate hydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To an ice cold solution of 4M HCl in dioxane (20 mL) was added (S)-methyl 2-((2-((tert-butoxycarbonyl)amino)butyl)amino)-2-oxoacetate (1.3 g, 4.6 mmol). After 30 minutes, the reaction mixture was concentrated to provide a yellow foam (968 mg, 100%), which was used without further purification. MS (ESI): mass calcd. for C7H14N2O3, 174.1; m/z found, 175.2 [M+H]+.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-bda0854d96414bc7a4b7580f3d972256
Source dataset
uspto-grants-2015_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09040534B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes