Cyanoacetic acid → HCID 59491624, compound

HRID 577407

Reaction equation

HRID 577407 reaction equation
[C:1]1([S:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([NH2:21])[CH:16]=3)[N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:22]([CH2:24][C:25](O)=[O:26])#[N:23]>>[C:1]1([S:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[C:17]([NH:21][C:25](=[O:26])[CH2:24][C:22]#[N:23])[CH:18]=[CH:19][CH:20]=3)[N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 9740Cyanoacetic acidHCID 68746426N1-(4-(phenylthio)pyrimidin-2-yl)benzene-1,3-diamine

Product 1

HCID 59491624HCID 59491624, compoundYield 47.1%

Procedure

In a procedure analogous to Example 15, reaction of N1-(4-(phenylthio)pyrimidin-2-yl)benzene-1,3-diamine (80 mg, 0.27 mmol) and cyanoacetic acid (46 mg, 0.54 mmol) furnished the product (46 mg, 47%).

Sources & evidence

ORD record
ord-0cf5cd354d8a4042af0824f57a71edb7
Source dataset
uspto-grants-2015_05
Patent number
US09040549B2

Linked notes

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