Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate
Reaction equation
[F:1][C:2]1[CH:12]=[C:11](F)[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH3:17]>C1COCC1>[NH2:17][C:11]1[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:2]([F:1])[CH:12]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared analogously to example 659a from ethyl 2,4-difluoro-5-nitro-benzoate and ammonia in THF.
Sources & evidence
- ORD record
- ord-530c8ba73c8c4ffdac6bae7c5736416c
- Source dataset
- uspto-grants-2015_05
- Patent number
- US09040565B2
Reaction notes
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