Methanesulfonyl chloride → N-(5-Bromo-6-methyl-2-pyridinyl)methanesulfonamide

HRID 58038

Reaction equation

HRID 58038 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:9])=[N:6][C:7]=1[CH3:8].C(N(C(C)C)C(C)C)C.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][S:20]([CH3:19])(=[O:22])=[O:21])=[N:6][C:7]=1[CH3:8]

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 1706782-Pyridinamine, 5-bromo-6-methyl-

Product 1

HCID 79049128N-(5-Bromo-6-methyl-2-pyridinyl)methanesulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 5-bromo-6-methylpyridin-2-amine (0.3 g, 1.604 mmol) and N-ethyl-N-isopropylpropan-2-amine (0.559 mL, 3.21 mmol) in DCM (10 mL) was added methanesulfonyl chloride (0.137 mL, 1.764 mmol) at 0° C. The reaction mixture was stirred at room temperature for 48 hours and was subsequently concentrated in vacuo to give the title compound.

Workup

  1. concentrationwas subsequently concentrated in vacuo

Sources & evidence

ORD record
ord-eff90a1b5e1d49ba85eea4a95d9dbafd
Source dataset
uspto-grants-2016_09
Patent number
US09434743B2

Linked notes

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