Ammonium Hydroxide → 5-Bromopyridine-2-sulfonamide
Reaction equation
Cl.[Br:2][C:3]1[CH:4]=[CH:5][C:6]([S:9](Cl)(=[O:11])=[O:10])=[N:7][CH:8]=1.[OH-].[NH4+:14]>>[Br:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([NH2:14])(=[O:11])=[O:10])=[N:7][CH:8]=1Participants
3
Conditions
- Temperature
- 70 °C
Procedure
To a 4 mL vial equipped with a magnetic stir bar were added 5-bromopyridine-2-sulfonyl chloride hydrochloride (250 mg, 0.853 mmol) and ammonium hydroxide (1329 μL, 34.1 mmol) to give a white suspension, which was heated to 70° C. in a sand bath overnight. The solvent was subsequently evaporated to give the title compound, which was used without further purification.
Workup
- customTo a 4 mL vial equipped with a magnetic stir bar
- customto give a white suspension, which
- customThe solvent was subsequently evaporated
Sources & evidence
- ORD record
- ord-079c2d860f624468a24d1ac13482ea9b
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434743B2
Reaction notes
Loading…