Phosphonic acid, [2-(4-morpholinyl)-2-oxoethyl]-, diethyl ester → 4-Amino-beta-(4-chlorophenyl)-3,5-dichloro-cinnamic acid morpholide

HRID 580605

Reaction equation

HRID 580605 reaction equation
[NH2:1][C:2]1[C:16]([Cl:17])=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=O)=[CH:4][C:3]=1[Cl:18].C(OP([CH2:27][C:28]([N:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1)=[O:29])(OCC)=O)C.CC(C)([O-])C.[K+]>CN(C)C=O>[NH2:1][C:2]1[C:16]([Cl:17])=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[CH:27][C:28]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[O:29])=[CH:4][C:3]=1[Cl:18]

Participants

5

Reactant 3

HCID 11207805Phosphonic acid, [2-(4-morpholinyl)-2-oxoethyl]-, diethyl esterHCID 13373314HCID 13373314, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 545219194-Amino-beta-(4-chlorophenyl)-3,5-dichloro-cinnamic acid morpholide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared from 4-amino-3,4',5-trichlorobenzophenone, diethylphosphonoacetic acid morpholide and potassium tert.butoxide in dimethylformamide analogous to Example 4.

Sources & evidence

ORD record
ord-1c383d8d2cb64187a8b2c60fa2f6b66f
Source dataset
uspto-grants-1988_06
Patent number
US04753934

Linked notes

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