HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Ammonia → 5,6,7,8-Tetrahydro-2-phenyl-3-(benzoylaminoiminomethyl)imidazo[2,1-b]benzothiazole

HRID 580926
Notes
Print preview

Reaction equation

HRID 580926 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]3[N:13]([C:14]=2[CH:15]=O)[C:12]2[CH2:17][CH2:18][CH2:19][CH2:20][C:11]=2[S:10]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:21]([NH:29][NH2:30])(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.Cl.C(O)C.N>O>[C:1]1([C:7]2[N:8]=[C:9]3[N:13]([C:14]=2[CH:15]=[N:30][NH:29][C:21](=[O:28])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:12]2[CH2:17][CH2:18][CH2:19][CH2:20][C:11]=2[S:10]3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 222AmmoniaHCID 11955BenzoylhydrazineHCID 107316142-Phenyl-4,5,6,7,8-pentahydroimidazo[2,1-b]benzothiazole-3-carbaldehydeHCID 21887872Ethanol hydrochloride

Product 1

HCID 23145105,6,7,8-Tetrahydro-2-phenyl-3-(benzoylaminoiminomethyl)imidazo[2,1-b]benzothiazoleYield 84%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.28 g of 5,6,7,8-tetrahydro-2-phenyl-3-formylimidazo[2,1-b]benzothiazole and 0.15 g of benzohydrazide were stirred over night in 20 ml of a 0.1N hydrochloric acid-ethanol solution at room temperature and the precipitated crystal obtained by filtration. The crystals were dissolved in water and the solution was made alkaline by ammonia solution, then extracted by chloroform. The extract was washed with water and dried, then the solvent was distilled off and the residue was crystallized from ethyl acetate to obtain the desired substance in an amount of 0.35 g (yield of 84.0%).

Workup

  1. customthe precipitated crystal obtained by filtration
  2. extractionextracted by chloroform
  3. washThe extract was washed with water
  4. customdried
  5. distillationthe solvent was distilled off
  6. customthe residue was crystallized from ethyl acetate
  7. customto obtain the desired substance in an amount of 0.35 g (yield of 84.0%)

Sources & evidence

ORD record
ord-6b09b8036967419295bf960b4f73ea62
Source dataset
uspto-grants-1999_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05919799

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes