Hydrazine hydrate (1:1) → 4,5-Dihydro-5-methyl-6-(4-(4-oxo-1(4H)-pyridinyl)phenyl)-3(2H)-pyridazinone

HRID 5812

Reaction equation

HRID 5812 reaction equation
O.[NH2:2][NH2:3].[O:4]=[C:5]1[CH:10]=[CH:9][N:8]([C:11]2[CH:24]=[CH:23][C:14]([C:15]([CH:17]([CH3:22])[CH2:18][C:19](O)=[O:20])=O)=[CH:13][CH:12]=2)[CH:7]=[CH:6]1>O>[CH3:22][CH:17]1[C:15]([C:14]2[CH:23]=[CH:24][C:11]([N:8]3[CH:9]=[CH:10][C:5](=[O:4])[CH:6]=[CH:7]3)=[CH:12][CH:13]=2)=[N:3][NH:2][C:19](=[O:20])[CH2:18]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 99477483-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid

Product 1

HCID 1307024,5-Dihydro-5-methyl-6-(4-(4-oxo-1(4H)-pyridinyl)phenyl)-3(2H)-pyridazinone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Hydrazine hydrate (1.8 g) was added to a suspension of 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid (5 g) in water (60 ml). The resulting solution was stirred under reflux for 2 hours and cooled to afford the title compound as a pale yellow solid, 4.45 g, m.p. 255°-258° C.

Workup

  1. temperatureunder reflux for 2 hours
  2. temperaturecooled

Sources & evidence

ORD record
ord-9082b80c2ce84f57abe9c9a2c56ec958
Source dataset
uspto-grants-1993_09
Patent number
US05246928

Linked notes

Loading…